Russian scientists find new way to repair DNA that may cure Alzheimer’s

[Queen Titania]

A group of Russian scientists have discovered a new method of DNA repair which may be able to prevent and cure neurodegenerative diseases, such as Alzheimer’s or Parkinson’s and even stop the process of cell death.

The research team led by Vasily M. Studitsky, professor at the Lomonosov Moscow State University,published their findings in an article “Structure of transcribed chromatin is a sensor of DNA damage” in the Science Advances journal.

“Early detection and repair of damaged DNA is essential for cell functioning and survival,” says the study.

READ MORE: Survival genes: Scientists find DNA mutations that helped Russians during Leningrad siege

The paper raises the question of single-strand breaks (SSBs) which are called in the research “common DNA damages generated during various processes of cell metabolism.”

“Unrepaired SSBs can interfere with transcription, replication, and DNA repair; induce accumulation of double-stranded DNA breaks; increase genomic instability and apoptosis [process of programmed cell death]; and lead to severe neurodegenerative diseases.” Alzheimer’s, Parkinson’s disease and spinal muscular atrophy are examples of such diseases.

READ MORE: New research reveals why animals don’t get schizophrenia and humans do

Studitsky told science portal Psys.org that the team of scientists “has shown, not yet in the cell but in vitro, that the repair of breaks in the other DNA chain, which is ‘hidden’ in the nucleosome, is still possible.”

“According to our hypothesis, it occurs due to the formation of special small DNA loops in the nucleosome, although normally DNA wounds around the histone ‘spool’ very tightly," he added.

As the DNA molecule is chemically unstable, its damage detection and repair are needed.

“These observations raise the possibility that nucleosomal structure could affect the process of detection and repair of DNA damages,” the study says.

The researchers added that their findings can suggest “the existence of a chromatin-specific, transcription-dependent mechanism that allows detection of NT-SSBs that are otherwise hidden in the chromatin structure.”




http://rt.com/news/271774-russian-scientists-dna-repair/


Pray Big Pharma doesn't get its greedy hands on it --- They would give us all Alzheimer's just to make sure we all had to pay them a fortune to be rid of it.

 

[Addy]

I doubt that story being entirely factual, sorry. Do you have a link for a USA read on their claim?

 

[Addy]

Mechanisms of DNA Damage and Repair in Alzheimer Disease - Madame Curie Bioscience Database - NCBI Bookshelf

http://www.ncbi.nlm.nih.gov/books/NBK6019/

 

[Queen Titania]

I doubt that story being entirely factual, sorry. Do you have a link for a USA read on their claim?

US is Big Pharma --- why would I have?

 

[Queen Titania]

Mechanisms of DNA Damage and Repair in Alzheimer Disease - Madame Curie Bioscience Database - NCBI Bookshelf

http://www.ncbi.nlm.nih.gov/books/NBK6019/

I think though the Russians are saying they may have an actual way of repairing it.

 

[Addy]

I think though the Russians are saying they may have an actual way of repairing it.

If that's true, many accolades to them. But like I stated, until a scientific newsworthy paper puts out an announcment crediting the Russians with their discovery, I remain unconvinced.

 

[Queen Titania]

If that's true, many accolades to them. But like I stated, until a scientific newsworthy paper puts out an announcment crediting the Russians with their discovery, I remain unconvinced.

The research team led by Vasily M. Studitsky, professor at the Lomonosov Moscow State University,published their findings in an article “Structure of transcribed chromatin is a sensor of DNA damage” in the Science Advances journal.


http://advances.sciencemag.org/content/1/6/e1500021

 

[Addy]

The research team led by Vasily M. Studitsky, professor at the Lomonosov Moscow State University,published their findings in an article “Structure of transcribed chromatin is a sensor of DNA damage” in the Science Advances journal.


http://advances.sciencemag.org/content/1/6/e1500021

Credit for the article in your link above was also given to others, not just for Russians as far as I could determine.

↵* These authors contributed equally to this work.

@ the bottom of the read... Some American scientist are listed in the footnotes .

 

[Queen Titania]

Credit for the article in your link above was also given to others, not just for Russians as far as I could determine.

↵* These authors contributed equally to this work.

@ the bottom of the read... Some American scientist are listed in the footnotes .

Of course Addy 'no scientist is an island'. Honourable scientists always always give credit to others working on the same thing as well as those whose findings they are working from ---

If the understanding of any specific 'thing' is M then M is the point at which all scientist in that specific sphere work from --- and interact with each other.

 

[Addy]

Of course Addy 'no scientist is an island'. Honourable scientists always always give credit to others working on the same thing as well as those whose findings they are working from ---

If the understanding of any specific 'thing' is M then M is the point at which all scientist in that specific sphere work from --- and interact with each other.

Your link is a research article, I failed to see anywhere on that page, Russians being given credit for being able to repair DNA. They submitted their findings like the other scientist. imo.

 

[Fast Eddy]

This is great news. We have an aging population where this will grow as a bigger and bigger issue. There are claims being thrown around that they will soon be able to stop aging, so potentially this is very important if the aging cure doesn't halt Alzheimers.
They have ways of replacing genes and repairing DNA strands, its in its infancy, but several breakthroughs of late make it look very usable for fixing DNA related problems. This stuff seems to change daily as a ton of research going on.

 

[Queen Titania]

Your link is a research article, I failed to see anywhere on that page, Russians being given credit for being able to repair DNA. They submitted their findings like the other scientist. imo.

I c&ped the headline -- that's all.


The link within the link;-

Analysis of the genome structure of Leningrad siege survivors and their contemporaries has allowed Russian scientists to spot specific DNA mutations that helped people to live through one of the most tragic chapters of the WWII.

A team of researchers took blood samples from Leningrad siege survivors to analyze the structure of the genes involved in metabolism and cell activity when facing severe food shortages. They compared their findings with genetic samples of elderly Russians who did nt live through similar horrors.

Many siege survivors who suffered the worst turned out to have a completely different structure of two genes related to PPAR (peroxisome proliferator-activated receptors) proteins, and one from the UCP (uncoupling proteins) gene family, which play major roles in development, metabolism and thermogenesis of higher organisms.

The inhabitants of the besieged city, now known as St. Petersburg, had these genes undergo a mutation that increased the efficiency of the cells’ activities and reduced the loss of energy invested in keeping the body warm, according to an article, recently published in the journal Science.



Read more872 days of cold, hunger & death: Leningrad siege survivors share memories with RT


The project started about 15 years ago, when professor Oleg Glotov from the Ott Research Institute of Obstetrics and Gynecology in St. Petersburg, along with his colleagues, decided to study the problems of aging and longevity.

They collected some 200 blood samples of the aged, noticed some intriguing differences and decided to narrow their research to focus on the toughest ones – those people, who survived the siege and whose diet was limited by the harsh conditions of wartime.

“Genetic predisposition alongside with other factors was that very sieve which those siege survivors had to pass and managed to survive in that demanding environment. Absolutely, those genes did nt emerge by chance, in other words, those people already had them,” Glotov told RT. “About 20 to 30 percent of the population has those markers.”

“In harsh conditions they presented an advantage. In a stuffed environment, vice versa, they will be a disadvantage: in the case of overeating they will contribute to the accretion of energy in the form of fats, etc.,” he added.

Leningradians cleaning a street after the first winter in the besieged city. (RIA Novosti/Vsevolod Tarasevich)



For 872 days, from September 8, 1941 until January 27, 1944, residents of the Russian city of Leningrad were encircled by Nazi forces, cut off entirely from the rest of the country – with no food or vital supplies to rely on. The city was constantly bombed and people died continually of starvation and extreme cold. The harrowing winter of 1941-42 saw temperatures plunge to 40 degrees Celsius below zero, and with no heating Leningrad’s water supply network had frozen solid. People had to collect water from holes in the ice on the frozen Neva River.

Residents endured unprecedented food shortages, and a strict rationing system was in place in the city with individual daily food consumption limited to some 125 grams of bread. At one point the death toll was estimated at 100,000 people per month, with many forced to eat pets, rats or glue. Many were driven to madness while some resorted to cannibalism.

READ MORE: Appalling truth of Leningrad siege: 95yo Russian writer gives powerful speech at Bundestag

While the total death toll still remains unclear, estimates of the victims from the deadliest siege in the history of warfare vary, with some numbering up to 1.5 million civilians.

Scientists hope their findings may be useful in developing ways to combat obesity, anorexia and other disorders related to the metabolism.

“We would like to proceed with this research. At the moment in collaboration with Saint Petersburg state university a large biobank of samples is being created,” Glotov said.

“And we would like for this severest experiment and the experience that our fellow citizens and those who survived in those conditions got to make a contribution – not only as themselves or by the means of their children, but also as some samples of material, useful for science, which we could study further and determine the peculiarities of this phenomenon.”

 

[Addy]

I c&ped the headline -- that's all.

The Russian papers and their claims of grand scale scientific discoveries are very often propaganda.

 

[Addy]

This is great news. We have an aging population where this will grow as a bigger and bigger issue. There are claims being thrown around that they will soon be able to stop aging, so potentially this is very important if the aging cure doesn't halt Alzheimers.
They have ways of replacing genes and repairing DNA strands, its in its infancy, but several breakthroughs of late make it look very usable for fixing DNA related problems. This stuff seems to change daily as a ton of research going on.

With lots of potential for the masses throughout the world, easy to see why Russia would like to lay claim to making a unique discovery. They contibuted to the research paper as did many other scholars and scientist working on DNA repair.

 

[Queen Titania]

The Russian papers and their claims of grand scale scientific discoveries are very often propaganda.

What? Whats the matter with you Addy?

These findings have come out of research which was done specifically on survivors of the Leningrade Siege ---- done by Russian scientists. Soooo what is the big deal? Most breakthroughs are French or Italian (though they rarely get the credit) is it though impossible that the Russians have breakthroughs too?

 

[Queen Titania]

With lots of potential for the masses throughout the world, easy to see why Russia would like to lay claim to making a unique discovery. They contibuted to the research paper as did many other scholars and scientist working on DNA repair.

So it is more important to you that America get the credit than the actual findings themselves --- cool take it, you always do anyway ---- you are being utterly ridiculous Addy.

 

[Addy]

So it is more important to you that America get the credit than the actual findings themselves --- cool take it, you always do anyway ---- you are being utterly ridiculous Addy.

Your defense of Russia is what's ridiculous as well as your put down of America.

 

[Queen Titania]

Your defense of Russia is what's ridiculous as well as your put down of America.

In this instance I am not defending Russia but a couple of scientists who happen to be Russian scientists ---- When the US stops its destruction of the Planet and standing in the way of all forms of freedom I shall cease my criticism of it with the greatest of pleasure.

This thread is about another step toward healing not about false pride.

 

[Addy]

In this instance I am not defending Russia but a couple of scientists who happen to be Russian scientists ---- When the US stops its destruction of the Planet and standing in the way of all forms of freedom I shall cease my criticism of it with the greatest of pleasure.

This thread is about another step toward healing not about false pride.

When American scientist have breakthroughs... updates on health related matters. What I have noticed from you, it's all a conspiracy of some kind re our govt. Vaccines are bad, medicines are bad, foods are bad... and so on.
Continue on with your love affair with Russia. I am finished with the thread.

 

[Queen Titania]

When American scientist have breakthroughs... updates on health related matters. What I have noticed from you, it's all a conspiracy of some kind re our govt. Vaccines are bad, medicines are bad, foods are bad... and so on.
Continue on with your love affair with Russia. I am through the thread.

Good ---

What comes of this is yet to be seen --- but at least we know some of what is being found.