The idea of sanctification; the act of setting oneself aside for the Lord's use, is really mostly the answer of a good conscience to the Lord's act of holiness; which is his setting us aside for his use. So we say "Amen". Then we discipline ourselves to follow his leading and it is that walk that follows the strait and narrow path of discipleship. this is not quite the same as us separating ourselves from the world, that sort of implies that we take the lead and do some type of religious service... not quite the same as simply following the lord, following his holy spirit.
It isn't walking away from the world, it is following the holy spirit... where ever he leads.
I found Jesus outside of organized religion. I grew up an atheist, so religious concepts don't readily make much sense to me. I'm more inclined to go the scientific route... sex to me is just another bodily function, I don't attach all the sinfulness to the act that religion does. That's not to say that scripture doesn't offer good advice about when it is wise and when it is unwise to engage the act, but I had to learn all that, it wasn't part of my upbringing. So when I found Jesus I wasn't interested in organized religion, I was just following Christ in my heart. Then, he led me into organized religion for about 11 years, and boy did he lead me into the thick of it all. I even did a one year training for ministry in one of the many ministries I participated in, and I studied textual criticism and got to the point where I could read New Testament Greek; not from ever learning the language but just from all my study in the texts. And then the holy spirit told me to quit all that, and he led me back out of the churches, back into the wilderness where I began. So, for me, it has been 28 years in the wilderness. My son calls me a hermit, I have to admit, I enjoy the quiet, I don't need to constantly fill my ears with sound or talk, quiet works for me.
But the only thing that matters is that I have followed the holy spirit for whatever amount of time that I did. That's the slow transformation that changes us into a new being. Day by day, little by little, we grow in the spirit the same as we grew in the flesh. Personally, that's all that matters, the individual Christian only answers to Christ. we go where he leads us. simple.
The global movement away from Babylon into the wilderness was scripted by St John 2000 years ago, but it was practically word for word from Jeremiah some 600+ years earlier, so it was part and parcel to the day of the Lord from before the meaning of the prophecy was revealed. there is other places in prophecy where it is revealed that these structures, like the giant churches in Russia, and all those cathedrals in Europe, and the "mega-churches" in America, will go vacant during the kingdom, they will become like medieval castles are to us today; belonging to another era, when man was an idiot.